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A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor.
Raimi OG, Hurtado-Guerrero R, Borodkin V, Ferenbach A, Urbaniak MD, Ferguson MAJ, van Aalten DMF. Raimi OG, et al. RSC Chem Biol. 2020 Mar 24;1(1):13-25. doi: 10.1039/c9cb00017h. eCollection 2020 Apr 16. RSC Chem Biol. 2020. PMID: 34458745 Free PMC article.
Targeting a critical step in fungal hexosamine biosynthesis.
Lockhart DEA, Stanley M, Raimi OG, Robinson DA, Boldovjakova D, Squair DR, Ferenbach AT, Fang W, van Aalten DMF. Lockhart DEA, et al. Among authors: raimi og. J Biol Chem. 2020 Jun 26;295(26):8678-8691. doi: 10.1074/jbc.RA120.012985. Epub 2020 Apr 27. J Biol Chem. 2020. PMID: 32341126 Free PMC article.
N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.
Fang W, Robinson DA, Raimi OG, Blair DE, Harrison JR, Lockhart DE, Torrie LS, Ruda GF, Wyatt PG, Gilbert IH, van Aalten DM. Fang W, et al. Among authors: raimi og. ACS Chem Biol. 2015 Jun 19;10(6):1425-34. doi: 10.1021/cb5008647. Epub 2015 Feb 27. ACS Chem Biol. 2015. PMID: 25706802 Free PMC article.
Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells.
Kakade P, Ojha H, Raimi OG, Shaw A, Waddell AD, Ault JR, Burel S, Brockmann K, Kumar A, Ahangar MS, Krysztofinska EM, Macartney T, Bayliss R, Fitzgerald JC, Muqit MMK. Kakade P, et al. Among authors: raimi og. Open Biol. 2022 Jan;12(1):210264. doi: 10.1098/rsob.210264. Epub 2022 Jan 19. Open Biol. 2022. PMID: 35042401 Free PMC article.
15 results